Flucloxacillin

Penicillin antibacterial

For more detailed drug information, see Flucloxacillin in the AMH.

Dosage – Flucloxacillin

Length of course depends on the infection and its response to treatment.

Staphylococcal infections (not MRSA)

Birth (at term) – 1 week, IV/oral 25–50 mg/kg every 12 hours. Up to 100 mg/kg IV every 12 hours has been recommended for serious infections such as osteomyelitis.

1 week – 1 month, IV/oral 25–50 mg/kg every 8 hours. Up to 100 mg/kg IV every 8 hours has been recommended for serious infections such as osteomyelitis.

1 month – 18 years, oral 12.5–25 mg/kg (usual adult dose 250–500 mg) every 6 hours. For severe infections (eg osteomyelitis), use up to 1 g every 6 hours.

1 month – 18 years, IV/IM, usually 25 mg/kg (maximum 1 g) every 6 hours. For severe infections (eg endocarditis), use up to 50 mg/kg (maximum 2 g) every 4–6 hours.

Administration advice

Best absorbed if taken on an empty stomach.

For information about parenteral administration, see the Royal Children's Hospital Paediatric Injectable Guidelines.

Practice points

• flucloxacillin has a bitter taste (not disguised by the oral liquid formulation)

• consider dosage adjustment in renal impairment

Products

Search for Flucloxacillin on the PBS

• cap, 250 mg, 24, Flopen, Staphylex, PBS‑R¹

• cap, 500 mg, 24, Flopen, Staphylex, PBS‑R¹/PBS‑A[48]²

• oral liquid, 25 mg/mL (powder), 100 mL, Flucil, PBS‑R¹

• oral liquid, 50 mg/mL (powder), 100 mL, Flucil, PBS‑R¹

• inj, 500 mg (powder), 5, Flubiclox, Flucil^a

• inj, 1 g (powder), 10, Flubiclox^a

¹ serious staphylococcal infections

² osteomyelitis

^a generic brands available